Trimethyl Silyl lodide
Description
Trimethyl silyl iodide is a highly reactive reagent used in organic synthesis for mild deprotection and activation reactions, especially where acidic conditions are unsuitable.
Category
Pharmaceutical Intermediates
CAS no
16029-98-4
Formula
C3H9ISi
Synonyms
Trimethyliodosilane
Uses
• Cleavage of esters → carboxylic acids
• Cleavage of ethers (especially methyl/benzyl ethers)
• Deprotection of acetals and ketals
• Conversion of alcohols to alkyl iodides
• Widely used in pharmaceutical, nucleoside, and fine chemical synthesis
